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Cell Wars

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Cell Wars

Immune cells vs. invaders: it's a war going on in every healthy human body. When the combatants travel to space, say NASA scientists, curious things happen...

NASA

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January 23, 2002:  When you wake up, maybe you yawn, switch off your alarm clock, and listen for the perking of an automatic coffee maker -- a normal morning routine on Earth.

But if you were in orbit, the first thing you'd do is take a little roll of cotton, swish it around in your mouth, and then drop it in a tube filled with preservative. The cotton collects viruses, and the goal of that good-morning ritual is to help determine why astronaut saliva contains more viruses in space than it does on the ground.

Above: Small, capsule-shaped bacteria in this artist's rendering are being "swallowed" by an immune cell's oozing outer membrane. Credit and copyright: Scott Barrows.

It's not a trivial question.

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Our bodies are chock-full of tiny invaders: bacteria, viruses, protozoans. Multitudes inhabit our gut, more slip in on the food we eat and through the air we breathe. Usually they're not a problem. Indeed, some are even helpful -- and the ones that aren't are kept in check by our vigorous immune system, which marks and destroys pathogens before they get out of control. Without immune systems, humans would die.

In space, our immune system functions differently. This complex system consists, essentially, of disease-fighting cells that can travel throughout the body. There are many kinds of immune cells; two of the most important are B-cells, which send out antibodies -- proteins that latch onto germs or other problem-causing invaders, flagging them as invaders to be destroyed, and T-cells, which are the soldiers of the system, physically attacking and destroying pathogens.

In space, these cells don't work the way they do on the ground. T-cells, for example, don't multiply properly; there aren't as many of them as there should be. They can't move well. They don't signal each other as effectively. Overall, they seem less able to destroy invading germs.

Below: On Earth, a smaller T-cell (arrow) attacks and kills a much larger influenza virus-infected target. See the movie and learn more from CellsAlive.com.

Here on Earth, doctors have learned that stress can suppress the immune system by causing the body to release hormones that affect the way T-cells behave. Likewise, the unique physical and psychological stresses of space flight (takeoff and landing, for example) might trigger immune-altering hormones. Another possibility is that something about space itself -- weightlessness, perhaps, and not hormones at all -- might affect immune cells directly.

To help solve the mystery, researchers are using a NASA-developed "rotating bioreactor," which provides a reasonable analog of microgravity here on Earth. Neal Pellis, chief of the Biological Systems Office in the Johnson Space Center, explains: The core of the bioreactor is a soup-can size container that spins at the leisurely rate of 14 rpm. It allows cells to remain suspended for months at a time in continual free fall. Within their fluid environment, the tumbling cells fall toward Earth as fast as they can -- just as they would in Earth orbit.

Using the bioreactor, researchers can separate the immune system from its hormonal controls. Rather than looking at the human immune system as a whole, Pellis and his colleagues can examine the possible effects of low-gravity on individual immune cells.

Right: The heart of the bioreactor is a rotating wall vessel, shown here without its support equipment. [more]

In the bioreactor, says Pellis, cells begin to change within the first 15 minutes. Indeed, one of the first alterations researchers observe could possibly trigger all the other effects: T-cells are somehow forced to remain round.  

It's an important change. On Earth, these cells can alter their shape. They're able to protrude portions of themselves -- an ability that they use to move around, just like amoebas do. And they need to move in order to do their job: They travel to the sites of infections, where they attack germs. They move to the sites of tumors. They locomote in and out of immune system organs, such as the appendix and tonsils, where other T-cells share samples of invading pathogens.

But it's not only the ability to move that's hampered by roundness. This simple change also makes it harder for cells to communicate. Round cells, explains Pellis, find it harder to touch each other. Their ability to interact is reduced.

Below: This animation illustrates the basic cell-to-cell interactions that lead to antibody production. T-cells must move and communicate with their cellular cousins to make the process work. [more]

Imagine two balloons, he says. "If you put them side by side, and pressed them together, the surface area that's in contact can be quite large." But, he says, if you have two bowling balls, no matter how hard you press them together, only a tiny fraction of their surfaces will meet. Such cells have less ability to exchange the chemical signals that command them to go into action

It's still unclear what these findings mean for the health of space travelers. Astronauts do show an increase in virus levels. For example, notes Duane Pierson, head of microbiology for the Johnson Space Center, when astronauts cough or sneeze, the droplets released contain 8 to 10 times more of the common Epstein-Barr virus (which causes infectious mononucleosis) than normal Earth sneezes. Although that's an indication of immune system suppression, the astronauts themselves have remained completely without symptoms.

Nor is it yet clear exactly what keeps T-cells round. Without the usual effects of gravity, explains Pellis, other forces --perhaps intermolecular or submolecular forces, such as hydrogen bonding -- must play a larger role, so that in microgravity, these other forces control the shape that the cell takes. "But exactly which forces are doing what to whom, where and how, to arrive at a spherical cell, I don't think anybody knows.”

Finding out is important ... and not only for astronauts. This research will also help people on Earth.

T-cells protect us from all kinds of problems, says Pellis, but they don't always behave as we would like. "There are times when we don't want them to invade -- transplants, for example. And there are cases when we want them to act vigorously, like in tumors."

Understanding the way physical forces affect T-cells could eventually allow scientists to control them -- "taming" them so that they help us, as they're meant to, in far more effective ways.

Above: Elements of the human immune system. Learn more from the National Institutes of Health.

Web Links

NASA's Office of Biological and Physical Research supports studies of the human body in space.

Immune system tutorials: Understanding the Immune System (basic); Immune System (intermediate); The Immune System (intermediate)

Lymphocytes: white blood cells that are key operatives of the immune system. The two major classes of lymphocytes are B cells and T cells.

CellsAlive.com: Animations and images of human cells. A great resource for novices.

Space research about the human immune system began in the Apollo era when blood samples from astronauts (collected in orbit and analyzed on the ground) revealed fewer-than-normal lymphocytes. Since then immune system studies have also been conducted on Skylab, in the space shuttle, on the Russian space station Mir -- and will be done on the International Space Station. Follow the links below to learn more:

The Biotechnology Space Support Center and the Space Biology Group in Zurich, Switzerland, have conducted many immune system experiments aboard space station Mir, NASA's space shuttle, rockets and stratospheric balloons. Highlights include the first in vitroactivation of lymphocytes in space in 1983 on the STS-9 Spacelab 1 mission, and cosmonaut skin tests, which measure how forcefully the body responds to pathogens.

Two immune system experiments recently flew to space on board shuttle Endeavour (STS-108): "Spaceflight-induced Reactivation of the Epstein-Barr Virus" and "Space Flight and Immune Function." Learn more from the experiments section of the STS-108 press kit: 2 MB pdf file.

Shuttle-Mir Human Immunology Experiments -- (SpaceFlight.NASA.gov) The Shuttle-Mir program included several immunology experiments that were designed to understand changes in the immune system's components that occur during long stays in space.

IMMUNE.2 -- in 1995 shuttle Discovery (STS-63) carried aloft one dozen male rats to study the effects of spaceflight on their immune systems. IMMUNE.2 extended a similar study named IMMUNE.1, which flew to space aboard STS-60 in 1994.

STS-55 experiment focuses on lymphocyte activation -- A German-American study targets the behavior of B cells in space.

Bioreactor expands health research -- (Science@NASA) This NASA device adds a new dimension to cell science.

Bioreactor flies aboard STS-90 for immune system research -- a 1998 NASA press release.

Immunology, Infection and Hematology -- ongoing research at the National Space Biomedical Research Institute, includes a note about Earth benefits.


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